Hoxb5 reprograms B cells into functional T lymphocytes

Deletion of B cell master regulators reprogrammed B cells into T cells that were either functional defects or tumorigenic potential. Here we show that Hoxb5, which is expressed in uncommitted hematopoietic progenitors but absent in committed B and T lineages, could reprogram pro-pre-B cells into fun...

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Détails bibliographiques
Publié dans:Nat Immunol
Auteurs principaux: Zhang, Mengyun, Dong, Yong, Hu, Fangxiao, Yang, Dan, Zhao, Qianhao, Lv, Cui, Wang, Ying, Xia, Chengxiang, Weng, Qitong, Liu, Xiaofei, Li, Chen, Zhou, Peiqing, Wang, Tongjie, Guan, Yuxian, Guo, Rongqun, Liu, Lijuan, Geng, Yang, Wu, Hongling, Du, Juan, Hu, Zheng, Xu, Sheng, Chen, Jiekai, He, Aibin, Liu, Bing, Wang, Demin, Yang, Yong-Guang, Wang, Jinyong
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6190911/
https://ncbi.nlm.nih.gov/pubmed/29434353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0046-x
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