OKN-007 Decreases Tumor Necrosis and Tumor Cell Proliferation and Increases Apoptosis in a Preclinical F98 Rat Glioma Model

BACKGROUND: Glioblastoma is a malignant World Health Organization (WHO) grade IV glioma with a poor prognosis in humans. New therapeutics are desperately required. The nitrone OKN-007 (2,4-disulfophenyl-PBN) has demonstrated effective anti-glioma properties in several rodent models and is currently...

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Detalhes bibliográficos
Publicado no:J Magn Reson Imaging
Main Authors: de Souza, Patricia Coutinho, Balasubramanian, Krithika, Njoku, Charity, Smith, Natalyia, Gillespie, David L., Schwager, Andrea, Abdullah, Osama, Ritchey, Jerry W., Fung, Kar-Ming, Saunders, Debra, Jensen, Randy L., Towner, Rheal A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6190608/
https://ncbi.nlm.nih.gov/pubmed/25920494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmri.24935
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