The Endonucleolytic RNA Cleavage Function of nsp1 of Middle East Respiratory Syndrome Coronavirus Promotes the Production of Infectious Virus Particles in Specific Human Cell Lines

Middle East respiratory syndrome coronavirus (MERS-CoV) nsp1 suppresses host gene expression in expressed cells by inhibiting translation and inducing endonucleolytic cleavage of host mRNAs, the latter of which leads to mRNA decay. We examined the biological functions of nsp1 in infected cells and i...

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Bibliographic Details
Published in:J Virol
Main Authors: Nakagawa, Keisuke, Narayanan, Krishna, Wada, Masami, Popov, Vsevolod L., Cajimat, Maria, Baric, Ralph S., Makino, Shinji
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189501/
https://ncbi.nlm.nih.gov/pubmed/30111568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01157-18
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