Early IFNγ-Mediated and Late Perforin-Mediated Suppression of Pathogenic CD4 T Cell Responses Are Both Required for Inhibition of Demyelinating Disease by CNS-Specific Autoregulatory CD8 T Cells

Pathogenesis of immune-mediated demyelinating diseases like multiple sclerosis (MS) is thought to be governed by a complex cellular interplay between immunopathogenic and immunoregulatory responses. We have previously shown that central nervous system (CNS)-specific CD8 T cells have an unexpected pr...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Boyden, Alexander W., Brate, Ashley A., Karandikar, Nitin J.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189364/
https://ncbi.nlm.nih.gov/pubmed/30356717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02336
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