Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study

BACKGROUND: Gemcitabine is used to treat a wide range of tumours, but its efficacy is limited by cancer cell resistance mechanisms. NUC-1031, a phosphoramidate modification of gemcitabine, is the first anti-cancer ProTide to enter the clinic and is designed to overcome these key resistance mechanism...

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Publicado no:Br J Cancer
Main Authors: Blagden, Sarah P., Rizzuto, Ivana, Suppiah, Puvan, O’Shea, Daniel, Patel, Markand, Spiers, Laura, Sukumaran, Ajithkumar, Bharwani, Nishat, Rockall, Andrea, Gabra, Hani, El-Bahrawy, Mona, Wasan, Harpreet, Leonard, Robert, Habib, Nagy, Ghazaly, Essam
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6189138/
https://ncbi.nlm.nih.gov/pubmed/30206366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0244-1
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