Detection of CRISPR-dCas9 on DNA with Solid-State Nanopores

[Image: see text] Solid-state nanopores have emerged as promising platforms for biosensing including diagnostics for disease detection. Here we show nanopore experiments that detect CRISPR-dCas9, a sequence-specific RNA-guided protein system that specifically binds to a target DNA sequence. While CR...

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Veröffentlicht in:Nano Lett
Hauptverfasser: Yang, Wayne, Restrepo-Pérez, Laura, Bengtson, Michel, Heerema, Stephanie J., Birnie, Anthony, van der Torre, Jaco, Dekker, Cees
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2018
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187524/
https://ncbi.nlm.nih.gov/pubmed/30187755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.8b02968
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