Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme

[Image: see text] Based on the idea that compounds designed to exhibit high affinity for heme would block hemozoin formation, a critical heme-detoxification process for malarial parasites, we synthesized a series of compounds with two π-conjugated moieties at terminal amino groups of triamine. These...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Sakata, Yosuke, Yabunaka, Kosuke, Kobayashi, Yuko, Omiya, Hirohisa, Umezawa, Naoki, Kim, Hye-Sook, Wataya, Yusuke, Tomita, Yoshimi, Hisamatsu, Yosuke, Kato, Nobuki, Yagi, Hirokazu, Satoh, Tadashi, Kato, Koichi, Ishikawa, Haruto, Higuchi, Tsunehiko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2018
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187406/
https://ncbi.nlm.nih.gov/pubmed/30344903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00222
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