Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival

Nutrient restriction reprograms cellular signaling and metabolic network to shape cancer phenotype. Lactate dehydrogenase A (LDHA) has a key role in aerobic glycolysis (the Warburg effect) through regeneration of the electron acceptor NAD (+) and is widely regarded as a desirable target for cancer t...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Pathria, Gaurav, Scott, David A, Feng, Yongmei, Sang Lee, Joo, Fujita, Yu, Zhang, Gao, Sahu, Avinash D, Ruppin, Eytan, Herlyn, Meenhard, Osterman, Andrei L, Ronai, Ze'ev A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187221/
https://ncbi.nlm.nih.gov/pubmed/30209241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899735
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