Endolysosomal degradation of Tau and its role in glucocorticoid‐driven hippocampal malfunction

Emerging studies implicate Tau as an essential mediator of neuronal atrophy and cognitive impairment in Alzheimer's disease (AD), yet the factors that precipitate Tau dysfunction in AD are poorly understood. Chronic environmental stress and elevated glucocorticoids (GC), the major stress hormon...

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Gepubliceerd in:EMBO J
Hoofdauteurs: Vaz‐Silva, João, Gomes, Patrícia, Jin, Qi, Zhu, Mei, Zhuravleva, Viktoriya, Quintremil, Sebastian, Meira, Torcato, Silva, Joana, Dioli, Chrysoula, Soares‐Cunha, Carina, Daskalakis, Nikolaos P, Sousa, Nuno, Sotiropoulos, Ioannis, Waites, Clarissa L
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187216/
https://ncbi.nlm.nih.gov/pubmed/30166454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899084
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