ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis

Triple-negative breast cancer (TNBC) accounts for a disproportionately high number of deaths due to a lack of targeted therapies and an increased likelihood of distant recurrence. Estrogen receptor beta (ERβ), a well-characterized tumor suppressor, is expressed in 30% of TNBCs, and its expression is...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Reese, Jordan M., Bruinsma, Elizabeth S., Nelson, Adam W., Chernukhin, Igor, Carroll, Jason S., Li, Ying, Subramaniam, Malayannan, Suman, Vera J., Negron, Vivian, Monroe, David G., Ingle, James N., Goetz, Matthew P., Hawse, John R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187171/
https://ncbi.nlm.nih.gov/pubmed/30257941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807751115
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