ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis

Triple-negative breast cancer (TNBC) accounts for a disproportionately high number of deaths due to a lack of targeted therapies and an increased likelihood of distant recurrence. Estrogen receptor beta (ERβ), a well-characterized tumor suppressor, is expressed in 30% of TNBCs, and its expression is...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Reese, Jordan M., Bruinsma, Elizabeth S., Nelson, Adam W., Chernukhin, Igor, Carroll, Jason S., Li, Ying, Subramaniam, Malayannan, Suman, Vera J., Negron, Vivian, Monroe, David G., Ingle, James N., Goetz, Matthew P., Hawse, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187171/
https://ncbi.nlm.nih.gov/pubmed/30257941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807751115
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