ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis

Triple-negative breast cancer (TNBC) accounts for a disproportionately high number of deaths due to a lack of targeted therapies and an increased likelihood of distant recurrence. Estrogen receptor beta (ERβ), a well-characterized tumor suppressor, is expressed in 30% of TNBCs, and its expression is...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Reese, Jordan M., Bruinsma, Elizabeth S., Nelson, Adam W., Chernukhin, Igor, Carroll, Jason S., Li, Ying, Subramaniam, Malayannan, Suman, Vera J., Negron, Vivian, Monroe, David G., Ingle, James N., Goetz, Matthew P., Hawse, John R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187171/
https://ncbi.nlm.nih.gov/pubmed/30257941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807751115
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