ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB

The protein disaggregase ClpB hexamer is conserved across evolution and has two AAA+-type nucleotide-binding domains, NBD1 and NBD2, in each protomer. In M. tuberculosis (Mtb), ClpB facilitates asymmetric distribution of protein aggregates during cell division to help the pathogen survive and persis...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Yu, Hongjun, Lupoli, Tania J., Kovach, Amanda, Meng, Xing, Zhao, Gongpu, Nathan, Carl F., Li, Huilin
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187150/
https://ncbi.nlm.nih.gov/pubmed/30257943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810648115
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