Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice

Suramin (Sur) acts as an ecto-NTPDase inhibitor in Trypanosoma cruzi and a P2-purinoceptor antagonist in mammalian cells. Although the potent antitrypanosomal effect of Sur has been shown in vitro, limited evidence in vivo suggests that this drug can be dangerous to T. cruzi-infected hosts. Therefor...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oxid Med Cell Longev
Egile Nagusiak: Novaes, Rômulo D., Santos, Eliziária C., Cupertino, Marli C., Bastos, Daniel S. S., Mendonça, Andréa A. S., Marques-da-Silva, Eduardo de Almeida, Cardoso, Sílvia A., Fietto, Juliana L. R., Oliveira, Leandro L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Hindawi 2018
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6186315/
https://ncbi.nlm.nih.gov/pubmed/30364017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/7385639
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