Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice

Suramin (Sur) acts as an ecto-NTPDase inhibitor in Trypanosoma cruzi and a P2-purinoceptor antagonist in mammalian cells. Although the potent antitrypanosomal effect of Sur has been shown in vitro, limited evidence in vivo suggests that this drug can be dangerous to T. cruzi-infected hosts. Therefor...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Oxid Med Cell Longev
Glavni autori: Novaes, Rômulo D., Santos, Eliziária C., Cupertino, Marli C., Bastos, Daniel S. S., Mendonça, Andréa A. S., Marques-da-Silva, Eduardo de Almeida, Cardoso, Sílvia A., Fietto, Juliana L. R., Oliveira, Leandro L.
Format: Artigo
Jezik:Inglês
Izdano: Hindawi 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6186315/
https://ncbi.nlm.nih.gov/pubmed/30364017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/7385639
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items