Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice

Suramin (Sur) acts as an ecto-NTPDase inhibitor in Trypanosoma cruzi and a P2-purinoceptor antagonist in mammalian cells. Although the potent antitrypanosomal effect of Sur has been shown in vitro, limited evidence in vivo suggests that this drug can be dangerous to T. cruzi-infected hosts. Therefor...

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Библиографические подробности
Опубликовано в: :Oxid Med Cell Longev
Главные авторы: Novaes, Rômulo D., Santos, Eliziária C., Cupertino, Marli C., Bastos, Daniel S. S., Mendonça, Andréa A. S., Marques-da-Silva, Eduardo de Almeida, Cardoso, Sílvia A., Fietto, Juliana L. R., Oliveira, Leandro L.
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6186315/
https://ncbi.nlm.nih.gov/pubmed/30364017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/7385639
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