cGMP interacts with tropomyosin and downregulates actin-tropomyosin-myosin complex interaction

BACKGROUND: The nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway, plays a critical role in the pathogenesis of pulmonary arterial hypertension (PAH); however, its exact molecular mechanism remains undefined. METHODS: Biotin-cGMP pull-down assay wa...

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Bibliografski detalji
Izdano u:Respir Res
Glavni autori: Zou, Lihui, Zhang, Junhua, Han, Jingli, Li, Wenqing, Su, Fei, Xu, Xiaomao, Zhai, Zhenguo, Xiao, Fei
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6186101/
https://ncbi.nlm.nih.gov/pubmed/30314482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-018-0903-z
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