MiR-126 negatively regulates PLK-4 to impact the development of hepatocellular carcinoma via ATR/CHEK1 pathway

Emerging evidence has shown that microRNA-126 (miR-126) is aberrantly downregulated and plays a vital role in carcinogenesis in various cancers, including HCC. However, the underlying biological mechanisms of miR-126 in HCC are still largely unknown. In present study, we found that miR-126 was downr...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Bao, Jie, Yu, Yan, Chen, Jianan, He, Yuting, Chen, Xiaolong, Ren, Zhigang, Xue, Chen, Liu, Liwen, Hu, Qiuyue, Li, Juan, Cui, Guangying, Sun, Ranran
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6185973/
https://ncbi.nlm.nih.gov/pubmed/30315225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1020-0
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