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Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene
The c-MYC oncogene mediates multiple tumor cell survival pathways and is dysregulated or overexpressed in the majority of human cancers. The NHE III(1) region of the c-MYC promoter forms a DNA quadruplex. Stabilization of this structure with small molecules has been shown to reduce expression of c-M...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6185859/ https://ncbi.nlm.nih.gov/pubmed/30312328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0205584 |
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