Mutual activation of glutamatergic mGlu(4) and muscarinic M(4) receptors reverses schizophrenia-related changes in rodents

RATIONALE: Metabotropic glutamate receptors and muscarinic M(4) receptors have been proposed as novel targets for various brain disorders, including schizophrenia. Both receptors are coupled to G(o/i) proteins and are expressed in brain circuits that are important in schizophrenia. Therefore, their...

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Detalles Bibliográficos
Publicado en:Psychopharmacology (Berl)
Autores principales: Cieślik, Paulina, Woźniak, Monika, Rook, Jerri M., Tantawy, Mohammed N., Conn, P. Jeffrey, Acher, Francine, Tokarski, Krzysztof, Kusek, Magdalena, Pilc, Andrzej, Wierońska, Joanna M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Investigation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182605/
https://ncbi.nlm.nih.gov/pubmed/30054675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-018-4980-y
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