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Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

The instability of DNA triplexes particularly at neutral pH and above severely limits their applications. Here, we demonstrate that the introduction of a thiazole orange (TO) intercalator onto a thymine nucleobase in triplex forming oligonucleotides (TFOs) resolves this problem. The stabilising effe...

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Detaylı Bibliyografya
Yayımlandı:Chem Sci
Asıl Yazarlar: Walsh, Sarah, El-Sagheer, Afaf Helmy, Brown, Tom
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Royal Society of Chemistry 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182420/
https://ncbi.nlm.nih.gov/pubmed/30393529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc02418a
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