Increase in resistance to anticancer drugs involves occludin in spheroid culture model of lung adenocarcinoma A549 cells

Chemoresistance is a serious issue in the therapy of many cancers, but the molecular mechanism is little understood. The mRNA level of occludin (OCLN), a tight junctional protein, was increased in the cisplatin (CDDP), doxorubicin (DXR), 7-ethyl-10-hydroxy-camptothecin, or gemcitabine-resistant huma...

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Publicado en:Sci Rep
Main Authors: Eguchi, Hiroaki, Akizuki, Risa, Maruhashi, Ryohei, Tsukimoto, Mitsutoshi, Furuta, Takumi, Matsunaga, Toshiyuki, Endo, Satoshi, Ikari, Akira
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181945/
https://ncbi.nlm.nih.gov/pubmed/30310131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33566-w
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