Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells

The aberrant expression of claudins (CLDNs), which are tight junctional proteins, is seen in various solid tumors, but the regulatory mechanisms and their pathophysiological role are not well understood. Both CLDN1 and CLDN11 were highly expressed in human lung squamous cell carcinoma (SCC). Chrysin...

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Publicado no:Sci Rep
Main Authors: Maruhashi, Ryohei, Eguchi, Hiroaki, Akizuki, Risa, Hamada, Shohei, Furuta, Takumi, Matsunaga, Toshiyuki, Endo, Satoshi, Ichihara, Kenji, Ikari, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760125/
https://ncbi.nlm.nih.gov/pubmed/31551535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50276-z
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