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Oxidative Stress and Dietary Micronutrient Deficiencies Contribute to Overexpression of Epigenetically Regulated Genes by Lupus T Cells
Patients with active lupus have altered T cells characterized by low DNA methyltransferase levels. We hypothesized that low DNA methyltransferase levels synergize with low methionine levels to cause greater overexpression of genes normally suppressed by DNA methylation. CD4+ T cells from lupus patie...
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| Publicado no: | Clin Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6181796/ https://ncbi.nlm.nih.gov/pubmed/29654844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2018.04.003 |
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