Minimal Efficacy of Nitisinone Treatment in a Novel Mouse Model of Oculocutaneous Albinism, Type 3

PURPOSE: Oral nitisinone has been shown to increase fur and ocular pigmentation in a mouse model of oculocutaneous albinism (OCA) due to hypomorphic mutations in tyrosinase (TYR), OCA1B. This study determines if nitisinone can improve ocular and/or fur pigmentation in a mouse model of OCA type 3 (OC...

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Dades bibliogràfiques
Publicat a:Invest Ophthalmol Vis Sci
Autors principals: Onojafe, Ighovie F., Megan, Lucyanne H., Melch, Madeline G., Aderemi, Joseph O., Alur, Ramakrishna P., Abu-Asab, Mones S., Chan, Chi-Chao, Bernardini, Isa M., Albert, Jessica S., Cogliati, Tiziana, Adams, David R., Brooks, Brian P.
Format: Artigo
Idioma:Inglês
Publicat: The Association for Research in Vision and Ophthalmology 2018
Matèries:
Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181301/
https://ncbi.nlm.nih.gov/pubmed/30347088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-20293
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