The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

Glioblastoma is characterized by widespread genetic and transcriptional heterogeneity, yet little is known about the role of the epigenome in glioblastoma disease progression. Here, we present genome-scale maps of DNA methylation in matched primary and recurring glioblastoma tumors, using data from...

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Библиографические подробности
Опубликовано в: :Nat Med
Главные авторы: Klughammer, Johanna, Kiesel, Barbara, Roetzer, Thomas, Fortelny, Nikolaus, Kuchler, Amelie, Nenning, Karl-Heinz, Furtner, Julia, Sheffield, Nathan C., Datlinger, Paul, Peter, Nadine, Nowosielski, Martha, Augustin, Marco, Mischkulnig, Mario, Ströbel, Thomas, Alpar, Donat, Ergüner, Bekir, Senekowitsch, Martin, Moser, Patrizia, Freyschlag, Christian F., Kerschbaumer, Johannes, Thomé, Claudius, Grams, Astrid E., Stockhammer, Günther, Kitzwoegerer, Melitta, Oberndorfer, Stefan, Marhold, Franz, Weis, Serge, Trenkler, Johannes, Buchroithner, Johanna, Pichler, Josef, Haybaeck, Johannes, Krassnig, Stefanie, Mahdy Ali, Kariem, von Campe, Gord, Payer, Franz, Sherif, Camillo, Preiser, Julius, Hauser, Thomas, Winkler, Peter A., Kleindienst, Waltraud, Würtz, Franz, Brandner-Kokalj, Tanisa, Stultschnig, Martin, Schweiger, Stefan, Dieckmann, Karin, Preusser, Matthias, Langs, Georg, Baumann, Bernhard, Knosp, Engelbert, Widhalm, Georg, Marosi, Christine, Hainfellner, Johannes A., Woehrer, Adelheid, Bock, Christoph
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181207/
https://ncbi.nlm.nih.gov/pubmed/30150718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0156-x
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