GLI2 promotes cell proliferation and migration through transcriptional activation of ARHGEF16 in human glioma cells

BACKGROUND: The Hedgehog (Hh) signaling pathway plays critical roles in modulating embryogenesis and maintaining tissue homeostasis, with glioma-associated oncogene (GLI) transcription factors being the main mediators. Aberrant activation of this pathway is associated with various human malignancies...

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Publicado en:J Exp Clin Cancer Res
Autores principales: Huang, Dengliang, Wang, Yiting, Xu, Linlin, Chen, Limin, Cheng, Minzhang, Shi, Wei, Xiong, Huanting, Zalli, Detina, Luo, Shiwen
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180656/
https://ncbi.nlm.nih.gov/pubmed/30305138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0917-x
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