Gain of function in Mycobacterium bovis BCG Moreau due to loss of a transcriptional repressor

The Bacille Calmette-Guérin (BCG) vaccine comprises a family of genetically different strains derived by the loss of genomic regions (RDs) and other mutations. In BCG Moreau, loss of RD16 inactivates rv3405c (*) , encoding a transcriptional repressor that negatively regulates the expression of Rv340...

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Detalles Bibliográficos
Publicado en:Mem Inst Oswaldo Cruz
Autores principales: Monteiro-Maia, Renata, Correa, Paloma Rezende, Sousa-Vasconcelos, Periela da Silva, de Pinho, Rosa Teixeira, Mendonça-Lima, Leila
Formato: Artigo
Lenguaje:Inglês
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2018
Materias:
Short Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180650/
https://ncbi.nlm.nih.gov/pubmed/30328891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760180267
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