Combined study on clastogenic, aneugenic and apoptotic properties of doxorubicin in human cells in vitro

BACKGROUND: Doxorubicin is a widely used anticancer drug due to its broad spectrum of antitumor activity. Various mechanisms have been proposed for its cytostatic activity, including DNA intercalation, topoisomerase II inhibition, generation of free radicals and apoptosis. The present study aims to...

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Dades bibliogràfiques
Publicat a:J Biol Res (Thessalon)
Autors principals: Chondrou, Vasiliki, Trochoutsou, Katerina, Panayides, Andreas, Efthimiou, Maria, Stephanou, Georgia, Demopoulos, Nikos A.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180587/
https://ncbi.nlm.nih.gov/pubmed/30338246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40709-018-0089-z
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