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Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells
BACKGROUND AND AIMS: The activating mutation BRAF(V600E) is a frequent genetic event in papillary thyroid carcinomas (PTC). Mutation BRAF(V600E) is associated with the loss of a sodium/iodine symporter (NIS), and subsequent radioiodide-refractory (RAI) metastatic disease. Use of BRAF V600E inhibitor...
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| Publicado no: | Thyroid Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6180498/ https://ncbi.nlm.nih.gov/pubmed/30337961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13044-018-0057-6 |
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