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Diphthamide affects selenoprotein expression: Diphthamide deficiency reduces selenocysteine incorporation, decreases selenite sensitivity and pre-disposes to oxidative stress

The diphthamide modification of translation elongation factor 2 is highly conserved in eukaryotes and archaebacteria. Nevertheless, cells lacking diphthamide can carry out protein synthesis and are viable. We have analyzed the phenotypes of diphthamide deficient cells and found that diphthamide defi...

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Bibliografiske detaljer
Udgivet i:Redox Biol
Main Authors: Mayer, Klaus, Mundigl, Olaf, Kettenberger, Hubert, Birzele, Fabian, Stahl, Sebastian, Pastan, Ira, Brinkmann, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180344/
https://ncbi.nlm.nih.gov/pubmed/30312900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.09.015
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