Shank2 Mutant Mice Display Hyperactivity Insensitive to Methylphenidate and Reduced Flexibility in Social Motivation, but Normal Social Recognition

Mouse models of autism can be used to study evolutionarily conserved mechanisms underlying behavioral abnormalities in social communication and repetitive behaviors. SHANK genes code for synaptic scaffolding proteins at excitatory synapses and mutations in all SHANK genes have been associated with a...

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Bibliographic Details
Published in:Front Mol Neurosci
Main Authors: Ey, Elodie, Torquet, Nicolas, de Chaumont, Fabrice, Lévi-Strauss, Julie, Ferhat, Allain-Thibeault, Le Sourd, Anne-Marie, Boeckers, Tobias M., Bourgeron, Thomas
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180161/
https://ncbi.nlm.nih.gov/pubmed/30337855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00365
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