Shank2 Mutant Mice Display Hyperactivity Insensitive to Methylphenidate and Reduced Flexibility in Social Motivation, but Normal Social Recognition

Mouse models of autism can be used to study evolutionarily conserved mechanisms underlying behavioral abnormalities in social communication and repetitive behaviors. SHANK genes code for synaptic scaffolding proteins at excitatory synapses and mutations in all SHANK genes have been associated with a...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Ey, Elodie, Torquet, Nicolas, de Chaumont, Fabrice, Lévi-Strauss, Julie, Ferhat, Allain-Thibeault, Le Sourd, Anne-Marie, Boeckers, Tobias M., Bourgeron, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180161/
https://ncbi.nlm.nih.gov/pubmed/30337855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00365
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