Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides To Form Nitriles

[Image: see text] A palladium(II) catalyst, in the presence of Selectfluor, enables the efficient and chemoselective transformation of primary amides into nitriles. The amides can be attached to aromatic rings, heteroaromatic rings, or aliphatic side chains, and the reactions tolerate steric bulk an...

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Bibliographic Details
Published in:Org Lett
Main Authors: Al-Huniti, Mohammed H., Rivera-Chávez, José, Colón, Katsuya L., Stanley, Jarrod L., Burdette, Joanna E., Pearce, Cedric J., Oberlies, Nicholas H., Croatt, Mitchell P.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2018
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6179452/
https://ncbi.nlm.nih.gov/pubmed/30221526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b02422
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