Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells

Tyrosine kinase inhibitors (TKi) are effective against chronic myeloid leukemia (CML), but their inefficacy on leukemia stem cells (LSCs) may lead to relapse. To identify new druggable targets alternative to BCR/ABL, we investigated the role of the MEK5/ERK5 pathway in LSC maintenance in low oxygen,...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Tusa, Ignazia, Cheloni, Giulia, Poteti, Martina, Gozzini, Antonella, DeSouza, Ngoc Ho, Shan, Yi, Deng, Xianming, Gray, Nathanael S., Li, Shaoguang, Rovida, Elisabetta, Dello Sbarba, Persio
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178886/
https://ncbi.nlm.nih.gov/pubmed/30245209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.08.016
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