Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells

Tyrosine kinase inhibitors (TKi) are effective against chronic myeloid leukemia (CML), but their inefficacy on leukemia stem cells (LSCs) may lead to relapse. To identify new druggable targets alternative to BCR/ABL, we investigated the role of the MEK5/ERK5 pathway in LSC maintenance in low oxygen,...

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Pubblicato in:Stem Cell Reports
Autori principali: Tusa, Ignazia, Cheloni, Giulia, Poteti, Martina, Gozzini, Antonella, DeSouza, Ngoc Ho, Shan, Yi, Deng, Xianming, Gray, Nathanael S., Li, Shaoguang, Rovida, Elisabetta, Dello Sbarba, Persio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178886/
https://ncbi.nlm.nih.gov/pubmed/30245209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.08.016
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