Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells

Tyrosine kinase inhibitors (TKi) are effective against chronic myeloid leukemia (CML), but their inefficacy on leukemia stem cells (LSCs) may lead to relapse. To identify new druggable targets alternative to BCR/ABL, we investigated the role of the MEK5/ERK5 pathway in LSC maintenance in low oxygen,...

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Publicat a:Stem Cell Reports
Autors principals: Tusa, Ignazia, Cheloni, Giulia, Poteti, Martina, Gozzini, Antonella, DeSouza, Ngoc Ho, Shan, Yi, Deng, Xianming, Gray, Nathanael S., Li, Shaoguang, Rovida, Elisabetta, Dello Sbarba, Persio
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6178886/
https://ncbi.nlm.nih.gov/pubmed/30245209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.08.016
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