Loop diuretics decrease the renal elimination rate and increase the plasma levels of trimethylamine‐N‐oxide

AIMS: Trimethylamine‐N‐oxide (TMAO) is a novel cardiovascular risk marker. We explored the association of commonly used cardiovascular medications with TMAO levels in patients and validated the identified associations in mice. METHODS: Detailed history of drug treatment was recorded in 300 patients...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Latkovskis, G., Makarova, E., Mazule, M., Bondare, L., Hartmane, D., Cirule, H., Grinberga, S., Erglis, A., Liepinsh, E., Dambrova, M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177719/
https://ncbi.nlm.nih.gov/pubmed/30069897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13728
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