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Glycation of type I collagen selectively targets the same helical domain lysine sites as lysyl oxidase–mediated cross-linking

Nonenzymatic glycation of collagen has long been associated with the progressive secondary complications of diabetes. How exactly such random glycations result in impaired tissues is still poorly understood. Because of the slow turnover rate of most fibrillar collagens, they are more susceptible to...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Hudson, David M., Archer, Marilyn, King, Karen B., Eyre, David R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177574/
https://ncbi.nlm.nih.gov/pubmed/30143533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004829
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