Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling

Alpha-fetoprotein (AFP) has been recognized as a key regulator of cell proliferation in hepatocellular carcinoma (HCC). However, whether AFP functions in cancer cell autophagy remains unknown. This study investigated the effects of AFP on autophagy in HCC cells. The role of AFP was studied in two HC...

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Pubblicato in:Cell Death Dis
Autori principali: Wang, Shanshan, Zhu, Mingyue, Wang, Qiaoyun, Hou, Yuli, Li, Lei, Weng, Honglei, Zhao, Yan, Chen, Dexi, Ding, Huiguo, Guo, Junli, Li, Mengsen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177398/
https://ncbi.nlm.nih.gov/pubmed/30301886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1036-5
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