Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling

Alpha-fetoprotein (AFP) has been recognized as a key regulator of cell proliferation in hepatocellular carcinoma (HCC). However, whether AFP functions in cancer cell autophagy remains unknown. This study investigated the effects of AFP on autophagy in HCC cells. The role of AFP was studied in two HC...

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Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Wang, Shanshan, Zhu, Mingyue, Wang, Qiaoyun, Hou, Yuli, Li, Lei, Weng, Honglei, Zhao, Yan, Chen, Dexi, Ding, Huiguo, Guo, Junli, Li, Mengsen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177398/
https://ncbi.nlm.nih.gov/pubmed/30301886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1036-5
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