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Structural basis of substrate recognition and covalent inhibition of Cdu1 from Chlamydia trachomatis
Based on the similarity between the active sites of the deubiquitylating and deneddylating enzyme ChlaDub1 (Cdu1) and the evolutionary related protease adenain a target-hopping approach screening on a focused set of adenain inhibitors has been pursued. The thereby identified cyano-pyrimidine based i...
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| Publicado no: | ChemMedChem |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6177307/ https://ncbi.nlm.nih.gov/pubmed/30028574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800364 |
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