Structural basis of substrate recognition and covalent inhibition of Cdu1 from Chlamydia trachomatis

Based on the similarity between the active sites of the deubiquitylating and deneddylating enzyme ChlaDub1 (Cdu1) and the evolutionary related protease adenain a target-hopping approach screening on a focused set of adenain inhibitors has been pursued. The thereby identified cyano-pyrimidine based i...

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Pubblicato in:ChemMedChem
Autori principali: Ramirez, Yesid A., Adler, Thomas B., Altmann, Eva, Klemm, Theresa, Tiesmeyer, Christian, Sauer, Florian, Kathman, Stefan G., Statsyuk, Alexander V., Sotriffer, Christoph, Kisker, Caroline
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177307/
https://ncbi.nlm.nih.gov/pubmed/30028574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800364
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