Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference

Morphogenesis involves interactions of asymmetric cell populations to form complex multicellular patterns and structures comprised of distinct cell types. However, current methods to model morphogenic events lack control over cell-type co-emergence and offer little capability to selectively perturb...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Libby, Ashley RG, Joy, David A, So, Po-Lin, Mandegar, Mohammad A, Muncie, Jonathon M, Mendoza-Camacho, Federico N, Weaver, Valerie M, Conklin, Bruce R, McDevitt, Todd C
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Developmental Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177255/
https://ncbi.nlm.nih.gov/pubmed/30298816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36045
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