Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

Growing evidence supports the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate that pharmacological inhibition of brain DYRK1A is able to correct recognition memory deficits in three DS mouse models with...

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Bibliographic Details
Published in:Dis Model Mech
Main Authors: Nguyen, Thu Lan, Duchon, Arnaud, Manousopoulou, Antigoni, Loaëc, Nadège, Villiers, Benoît, Pani, Guillaume, Karatas, Meltem, Mechling, Anna E., Harsan, Laura-Adela, Limanton, Emmanuelle, Bazureau, Jean-Pierre, Carreaux, François, Garbis, Spiros D., Meijer, Laurent, Herault, Yann
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176987/
https://ncbi.nlm.nih.gov/pubmed/30115750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.035634
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