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The LTB(4)–BLT1 axis regulates the polarized trafficking of chemoattractant GPCRs during neutrophil chemotaxis

Neutrophils sense and respond to diverse chemotactic cues through G-protein-coupled receptors (GPCRs). However, the precise trafficking dynamics of chemoattractant GPCRs during neutrophil activation and chemotaxis remain unclear. Here, by using small-molecule inhibitors and CRISPR-based knockouts, w...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Subramanian, Bhagawat C., Moissoglu, Konstadinos, Parent, Carole A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176921/
https://ncbi.nlm.nih.gov/pubmed/30158177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.217422
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