Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

Metastasis remains a leading cause of cancer mortality due to the lack of specific inhibitors against this complex process. To identify compounds selectively targeting the metastatic state, we used the perinuclear compartment (PNC), a complex nuclear structure associated with metastatic behaviors of...

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Publicado no:Sci Transl Med
Main Authors: Frankowski, Kevin J., Wang, Chen, Patnaik, Samarjit, Schoenen, Frank J., Southall, Noel, Li, Dandan, Teper, Yaroslav, Sun, Wei, Kandela, Irawati, Hu, Deqing, Dextras, Christopher, Knotts, Zachary, Bian, Yansong, Norton, John, Titus, Steve, Lewandowska, Marzena A., Wen, Yiping, Farley, Katherine I., Griner, Lesley Mathews, Sultan, Jamey, Meng, Zhaojing, Zhou, Ming, Vilimas, Tomas, Powers, Astin S., Kozlov, Serguei, Nagashima, Kunio, Quadri, Humair S., Fang, Min, Long, Charles, Khanolkar, Ojus, Chen, Warren, Kang, Jinsol, Huang, Helen, Chow, Eric, Goldberg, Esthermanya, Feldman, Coral, Xi, Romi, Kim, Hye Rim, Sahagian, Gary, Baserga, Susan J., Mazar, Andrew, Ferrer, Marc, Zheng, Wei, Shilatifard, Ali, Aubé, Jeffrey, Rudloff, Udo, Marugan, Juan Jose, Huang, Sui
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176865/
https://ncbi.nlm.nih.gov/pubmed/29769289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aap8307
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