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Glucocorticoids cause mandibular bone fragility and suppress osteocyte perilacunar-canalicular remodeling
Osteocytes support dynamic, cell-intrinsic resorption and deposition of bone matrix through a process called perilacunar/canalicular remodeling (PLR). In long bones, PLR depends on MMP13 and is tightly regulated by PTH, sclerostin, TGFβ, and glucocorticoids. However, PLR is regulated differently in...
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| 發表在: | Bone Rep |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Elsevier
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6176786/ https://ncbi.nlm.nih.gov/pubmed/30306100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bonr.2018.09.004 |
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