Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins

The PI3K-Akt-mTOR signaling pathway is a master regulator of RNA translation. Pharmacological inhibition of this pathway preferentially and coordinately suppresses, in a 4EBP1/2-dependent manner, translation of mRNAs encoding ribosomal proteins. However, it is unclear whether mechanistic target of r...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Ben B., Qian, Changli, Gameiro, Paulo A., Liu, Chin-Chih, Jiang, Tao, Roberts, Thomas M., Struhl, Kevin, Zhao, Jean J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176620/
https://ncbi.nlm.nih.gov/pubmed/30224479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805782115
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