Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.

The immunosuppressant rapamycin (RAP) has been demonstrated to specifically inhibit the activity of p70 S6 kinase (p70s6k) and subsequent phosphorylation of ribosomal S6 protein in mammalian cells. Addition of RAP to proliferating lymphoid cells resulted in inhibition of protein synthesis before any...

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Bibliografiske detaljer
Main Authors: Terada, N, Patel, H R, Takase, K, Kohno, K, Nairn, A C, Gelfand, E W
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC45254/
https://ncbi.nlm.nih.gov/pubmed/7972087
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