Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.

The immunosuppressant rapamycin (RAP) has been demonstrated to specifically inhibit the activity of p70 S6 kinase (p70s6k) and subsequent phosphorylation of ribosomal S6 protein in mammalian cells. Addition of RAP to proliferating lymphoid cells resulted in inhibition of protein synthesis before any...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Terada, N, Patel, H R, Takase, K, Kohno, K, Nairn, A C, Gelfand, E W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45254/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7972087/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.24.11477
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