Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae

The precise impact of the somatotrope axis upon the immune system is still highly debated. We have previously shown that mice with generalized ablation of growth hormone (GH) releasing hormone (GHRH) gene (Ghrh(−/−)) have normal thymus and T-cell development, but present a marked spleen atrophy and...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Farhat, Khalil, Bodart, Gwennaëlle, Charlet-Renard, Chantal, Desmet, Christophe J., Moutschen, Michel, Beguin, Yves, Baron, Frédéric, Melin, Pierrette, Quatresooz, Pascale, Parent, Anne-Simone, Desmecht, Daniel, Sirard, Jean-Claude, Salvatori, Roberto, Martens, Henri, Geenen, Vincent G.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176084/
https://ncbi.nlm.nih.gov/pubmed/30333823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02175
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