Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation

Cyclic nucleotide-gated (CNG) and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are tetrameric non-specific cation channels in the plasma membrane that are activated by either cAMP or cGMP binding to specific binding domains incorporated in each subunit. Typical apparent affinit...

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Pubblicato in:Sci Rep
Autori principali: Otte, Maik, Schweinitz, Andrea, Bonus, Michele, Enke, Uta, Schumann, Christina, Gohlke, Holger, Benndorf, Klaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175941/
https://ncbi.nlm.nih.gov/pubmed/30297855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33050-5
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