ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

DNA damage can induce autophagy; however, the underlying mechanism remains largely unknown. Here we report that DNA damage leads to autophagy through ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition. DNA damage caused by ultraviolet light (UV) or alkylatin...

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Vydáno v:Nat Commun
Hlavní autoři: Liu, Mingdong, Zeng, Taoling, Zhang, Xin, Liu, Chunyan, Wu, Zhihui, Yao, Luming, Xie, Changchuan, Xia, Hui, Lin, Qi, Xie, Liping, Zhou, Dawang, Deng, Xianming, Chan, Hong-Lin, Zhao, Tong-Jin, Wang, Hong-Rui
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175864/
https://ncbi.nlm.nih.gov/pubmed/30297842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06556-9
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